PMID: 17608770

Kimura Y, Morita SY, Matsuo M, Ueda K
Mechanism of multidrug recognition by MDR1/ABCB1.
Cancer Sci. 2007 Sep;98(9):1303-10. Epub 2007 Jun 30., [PubMed]
Sentences
No. Mutations Sentence Comment
26 ABCB1 p.Gly185Val
X
ABCB1 p.Gly185Val 17608770:26:143
status: NEW
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 (2,15,16) A few years later, human MDR1 was isolated from the adrenal and it was found that cDNA, isolated from KB-C2.5, was associated with a Gly-to-Val substitution at position 185, in the predicted cytoplasmic loop between TM2 and TM3. Login to comment 81 ABCD1 p.Lys435Met
X
ABCD1 p.Lys435Met 17608770:81:83
status: NEW
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ABCC9 p.Lys1075Met
X
ABCC9 p.Lys1075Met 17608770:81:97
status: NEW
view ABCC9 p.Lys1075Met details
 (53) As the excretion of phospholipids and cholesterol was not observed with MDR2- K435M or MDR2-K1075M, in which the Walker A lysine in either NBF was substituted by methionine, MDR2 mediates lipid efflux in an ATP-dependent manner, like other ABC transporters; however, no lipid secretion was observed from HEK293 cells expressing MDR1, even in the presence of bile salts. Login to comment