ABCB2 p.Cys12Ser

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PMID: 19258317 [PubMed] Hozoji M et al: "Formation of two intramolecular disulfide bonds is necessary for ApoA-I-dependent cholesterol efflux mediated by ABCA1."
No. Sentence Comment
124 TABLE 1 Cysteine mutants of ABCA1 Protein ApoA-I binding Cholesterol efflux Mutations Wild type ϩ ϩ None C1S ϩ ϩ C54S C2S - - C75S C3S ϩ ϩ C81S C4S ϩ ϩ C195S C5S ϩ ϩ C215S C6S - - C309S C7S ϩ ϩ C355S C8S ϩ ϩ C504S C9S ϩ ϩ C626S C10S ϩ ϩ C791S C11S ϩ ϩ C1418S C12S ϩ ϩ C1429S C13S ϩ ϩ C1463S C14S ϩ ϩ C1465S C15S ϩ - C1477S C16S ϩ ϩ C1814S C2/6S - - C75S/C309S C11/12S ϩ ϩ C1418S/C1429S C13/14S - - C1463S/C1465S C13/14/15S - - C1463S/C1465S/C1477S C11/12/13/14S - - C1418S/C1429S/C1463S/C1465S C11/12/13/15S - - C1418S/C1429S/C1463S/C1477S C11/12/14/15S - - C1418S/C1429S/C1465S/C1477S C11/13/14/15S - - C1418S/C1463S/C1465S/C1477S C12/13/14/15S - - C1429S/C1463S/C1465S/C1477S C11/12/13/14/15S - - C1418S/C1429S/C1463S/C1465S/C1477S C2/6/13/14/15S - - C75S/C309S/C1463S/C1465S/C1477S Cys4#1 ϩ ϩ C54S/C81S/C195S/C215S/C355S/C504S/C626S/C791S/C1418S/C1429S/C1465S/1814S Cys4#2 ϩ ϩ C54S/C81S/C195S/C215S/C355S/C504S/C626S/C791S/C1418S/C1429S/C1463S/1814S Cys5 ϩ ϩ C54S/C81S/C195S/C215S/C355S/C504S/C626S/C791S/C1418S/C1429S/C1814S irreversibly abolished apoA-I binding to cells expressing ABCA1(Cys5)-GFP (supplemental Fig. 4).
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ABCB2 p.Cys12Ser 19258317:124:379
status: NEW
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PMID: 12505156 [PubMed] Heintke S et al: "Functional cysteine-less subunits of the transporter associated with antigen processing (TAP1 and TAP2) by de novo gene assembly."
No. Sentence Comment
84 FEBS 26839 19-12-02 S. Heintke et al./FEBS Letters 533 (2003) 42^46 43 by serines (C6S, C12S, C14S, C73S, C179S, C488S, C662S, C735S of TAP1; C70S, C213S, C353S, C363S, C571S, C641S of TAP2); however, cysteines located within predicted transmembrane helices were exchanged to alanines (C315A of TAP1; C197A, C209A of TAP2).
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ABCB2 p.Cys12Ser 12505156:84:89
status: NEW
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82 by serines (C6S, C12S, C14S, C73S, C179S, C488S, C662S, C735S of TAP1; C70S, C213S, C353S, C363S, C571S, C641S of TAP2); however, cysteines located within predicted transmembrane helices were exchanged to alanines (C315A of TAP1; C197A, C209A of TAP2).
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ABCB2 p.Cys12Ser 12505156:82:17
status: NEW
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