ABCMdb

PMID: 12505156

Heintke S, Chen M, Ritz U, Lankat-Buttgereit B, Koch J, Abele R, Seliger B, Tampe R
Functional cysteine-less subunits of the transporter associated with antigen processing (TAP1 and TAP2) by de novo gene assembly.
FEBS Lett. 2003 Jan 2;533(1-3):42-6., [PubMed]

Sentences

No. Mutations Sentence Comment

82 ABCB2 p.Cys12Ser ABCB3 p.Cys571Ser ABCB3 p.Cys209Ala ABCB3 p.Cys70Ser ABCB3 p.Cys197Ala ABCB3 p.Cys213Ser ABCB3 p.Cys641Ser ABCB3 p.Cys353Ser by serines (C6S, C12S, C14S, C73S, C179S, C488S, C662S, C735S of TAP1; C70S, C213S, C353S, C363S, C571S, C641S of TAP2); however, cysteines located within predicted transmembrane helices were exchanged to alanines (C315A of TAP1; C197A, C209A of TAP2). Login to comment 83 ABCB3 p.Cys394Val ABCB3 p.Cys540His Based on sequence alignments among TAP homologs from other species, two cysteines in TAP2 were replaced by histidine and valine (C394V and C540H). Login to comment 84 ABCB2 p.Cys12Ser ABCB3 p.Cys571Ser ABCB3 p.Cys209Ala ABCB3 p.Cys70Ser ABCB3 p.Cys197Ala ABCB3 p.Cys213Ser ABCB3 p.Cys641Ser ABCB3 p.Cys353Ser FEBS 26839 19-12-02 S. Heintke et al./FEBS Letters 533 (2003) 42^46 43 by serines (C6S, C12S, C14S, C73S, C179S, C488S, C662S, C735S of TAP1; C70S, C213S, C353S, C363S, C571S, C641S of TAP2); however, cysteines located within predicted transmembrane helices were exchanged to alanines (C315A of TAP1; C197A, C209A of TAP2). Login to comment 85 ABCB3 p.Cys394Val ABCB3 p.Cys540His Based on sequence alignments among TAP homologs from other species, two cysteines in TAP2 were replaced by histidine and valine (C394V and C540H). Login to comment