ABCA1 p.Tyr1206Glu
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PMID: 21402379
[PubMed]
Nonomura K et al: "Insulin down-regulates specific activity of ATP-binding cassette transporter A1 for high density lipoprotein biogenesis through its specific phosphorylation."
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154
Wild type, Y1206F and Y1206E were transfected to HEK293 cells (E).
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ABCA1 p.Tyr1206Glu 21402379:154:22
status: NEW176 For further verification of the specific phosphorylation at this residue by insulin, a negative charge was introduced to 1206 substituting tyrosine by glutamine, mimicking a phosphorylated form (Y1206E).
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ABCA1 p.Tyr1206Glu 21402379:176:195
status: NEW177 The expression levels of the Y1206 mutants (Y1206F and Y1206E) were comparable to that of wild type ABCA1 (Fig. 4E).
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ABCA1 p.Tyr1206Glu 21402379:177:55
status: NEW178 Lipid release by apoA-I was completely suppressed in the cells transiently expressing Y1206E mutant (Fig. 4F).
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ABCA1 p.Tyr1206Glu 21402379:178:86
status: NEW