ABCC8 p.Asp818Gly
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PMID: 9685357
[PubMed]
Menguy T et al: "The cytoplasmic loop located between transmembrane segments 6 and 7 controls activation by Ca2+ of sarcoplasmic reticulum Ca2+-ATPase."
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283
Thus, as an alternative model, the L6-7 loop could be a direct contributor in the control of Ca2ϩ binding to Ca2ϩ - ATPase, as deduced from (a) our previous demonstration that Ca2ϩ has some affinity for the Gly-808-Gly-994 peptide but not for the shorter Asp-818-Gly-994 peptide (p20 and p19, respectively; Ref. 32) and (b) the present data that show that the removal of some of the oxygen atoms (Asp 3 Ala) located in the region from Gly-808 to Asp-818 of the L6-7 loop decreases the affinity for calcium by almost 3 orders of magnitude.
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ABCC8 p.Asp818Gly 9685357:283:273
status: NEW