ABCC8 p.Ile93Leu
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PMID: 21233638
[PubMed]
Depatureaux A et al: "Impact of HIV-1 group O genetic diversity on genotypic resistance interpretation by algorithms designed for HIV-1 group M."
No.
Sentence
Comment
49
The following minor resistance mutations, defined by at least 1 of the 3 algorithms, were found in more than 75% of the sequences: L10V (75%), I15V (91%), E35N (97%), M36I (99%), K43T (75%), Q58E (97%), I62V (100%), I64V (84%), H69R (88%), A71V (94%), L89I (88%), and I93L (100%) (Fig. 1C).
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ABCC8 p.Ile93Leu 21233638:49:268
status: NEW113 Furthermore, HIV-OANT70 and HIV-2ROD reference sequences shared 6 resistance-associated mutations (M36I, Q58E, I62V, A71V, L89I, I93L) and 1 uncommon mutation (I13A).25-27 Thus, as for HIV-2,27-29 HIV-O natural polymorphism is likely to have consequences for susceptibility to the different PI.
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ABCC8 p.Ile93Leu 21233638:113:129
status: NEW