ABCC8 p.Val118Cys
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PMID: 21233638
[PubMed]
Depatureaux A et al: "Impact of HIV-1 group O genetic diversity on genotypic resistance interpretation by algorithms designed for HIV-1 group M."
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Sentence
Comment
34
At positions associated with resistance to NRTI, all HIV-O sequenced samples (67 of 67, 100%) harbored the uncommon mutations V118C and L210Y, and 3% (2 of 67) exhibited the T69N mutation (Fig. 1A).
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ABCC8 p.Val118Cys 21233638:34:126
status: NEW104 DISCUSSION We report here a wide range of natural polymorphism in the RT and protease regions in a large series of HIV-O samples issued from 68 ARV-naive patients, extending similar findings previously reported for smaller series.5,11-13,21 The uncommon mutations, V118C and L210Y, were found naturally present in 100% of the RT sequences.
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ABCC8 p.Val118Cys 21233638:104:265
status: NEW106 The phenotypic characteristics of the V118C and L210Y mutants are currently unknown and should be determined to assess their impact on viral susceptibility.
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ABCC8 p.Val118Cys 21233638:106:38
status: NEW