ABCC8 p.Ser1356Cys
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PMID: 18715873
[PubMed]
Masia R et al: "Functional clustering of mutations in the dimer interface of the nucleotide binding folds of the sulfonylurea receptor."
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Sentence
Comment
84
Consistent with expectations, two mutations that increased MgADP stimulation (A1510C and S1511C) also increased diazoxide stimulation; a mutation that decreased MgADP stimulation (D1513C) also decreased diazoxide stimulation; and a mutation that had no effect on MgADP stimulation (S1356C) had no effect on diazoxide stimulation (Fig. 2C).
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ABCC8 p.Ser1356Cys 18715873:84:282
status: NEW85 Consistent with expectations, two mutations that increased MgADP stimulation (A1510C and S1511C) also increased diazoxide stimulation; a mutation that decreased MgADP stimulation (D1513C) also decreased diazoxide stimulation; and a mutation that had no effect on MgADP stimulation (S1356C) had no effect on diazoxide stimulation (Fig. 2C).
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ABCC8 p.Ser1356Cys 18715873:85:282
status: NEW