ABCMdb

PMID: 18715873

Masia R, Nichols CG
Functional clustering of mutations in the dimer interface of the nucleotide binding folds of the sulfonylurea receptor.
J Biol Chem. 2008 Oct 31;283(44):30322-9. Epub 2008 Aug 20., [PubMed]

Sentences

No. Mutations Sentence Comment

84 ABCC8 p.Ser1356Cys Consistent with expectations, two mutations that increased MgADP stimulation (A1510C and S1511C) also increased diazoxide stimulation; a mutation that decreased MgADP stimulation (D1513C) also decreased diazoxide stimulation; and a mutation that had no effect on MgADP stimulation (S1356C) had no effect on diazoxide stimulation (Fig. 2C). Login to comment 85 ABCC8 p.Ser1356Cys Consistent with expectations, two mutations that increased MgADP stimulation (A1510C and S1511C) also increased diazoxide stimulation; a mutation that decreased MgADP stimulation (D1513C) also decreased diazoxide stimulation; and a mutation that had no effect on MgADP stimulation (S1356C) had no effect on diazoxide stimulation (Fig. 2C). Login to comment