ABCC8 p.His326Ala
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PMID: 15613469
[PubMed]
Bancila V et al: "Two SUR1-specific histidine residues mandatory for zinc-induced activation of the rat KATP channel."
No.
Sentence
Comment
6
Of them, two histidines (His-326 and His-332) were found to be critical for the activation of KATP by zinc, as confirmed by the double mutation H326A/H332A.
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ABCC8 p.His326Ala 15613469:6:144
status: NEW53 The double mutation H326A/H332A was done on the single cDNA mutant histidine 332 by using mutagenic primers (F/326 and R/326) introducing the H326A mutation.
X
ABCC8 p.His326Ala 15613469:53:20
status: NEWX
ABCC8 p.His326Ala 15613469:53:142
status: NEW139 In contrast, both mutations H326A and H332A, and even more so the double mutation H326A/H332A, converted the activation into inhibition.
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ABCC8 p.His326Ala 15613469:139:28
status: NEWX
ABCC8 p.His326Ala 15613469:139:82
status: NEW174 Mutations H326A and H327A and the double mutation H326A/H327A suppressed zinc activation of KATP.
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ABCC8 p.His326Ala 15613469:174:10
status: NEWX
ABCC8 p.His326Ala 15613469:174:50
status: NEW