ABCC8 p.Cys418Trp
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PMID: 9748559
[PubMed]
Arias HR et al: "Binding sites for exogenous and endogenous non-competitive inhibitors of the nicotinic acetylcholine receptor."
No.
Sentence
Comment
1363
The importance of the serine ring in regards to NCI binding is also based on the fact that mutations distant from this locus (e.g., Cys418 to Trp at KM4) have shown no alteration in PCP and tetracaine noncompetitive inhibition properties [144].
X
ABCC8 p.Cys418Trp 9748559:1363:132
status: NEW
PMID: 10541058
[PubMed]
Arias HR et al: "Role of local anesthetics on both cholinergic and serotonergic ionotropic receptors."
No.
Sentence
Comment
436
The fact that mutations other than at this locus, for instance Cys418 to Trp at the aM4, have shown no alteration in tetracaine noncompetitive inhibition properties [119] supports the above mentioned location.
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ABCC8 p.Cys418Trp 10541058:436:63
status: NEW