ABCC8 p.Ile89Thr
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PMID: 19556559
[PubMed]
Tahar R et al: "Molecular epidemiology of malaria in Cameroon. XXVIII. In vitro activity of dihydroartemisinin against clinical isolates of Plasmodium falciparum and sequence analysis of the P. falciparum ATPase 6 gene."
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59
PFA0310c) and K1 (GeneBank accession no.AB121051).Sequence alignment was performed using MacDNASIS Pro software (Hitachi Software Engineering Co.,Yokohama, Japan).The following amino acid substitutions were analyzed for each isolate: L263E, E431K, A623E, and S769N.The presence of novel amino acid residues was also noted.The amino acid substitution observed in some Thai isolates (I89T) was not studied because it was shown to be unrelated to drug sensitivity.12 RESULTS The in vitro responses to dihydroartemisinin were available for 234 isolates from 2001 through 2006 (n = 90 in 2001-2002, n = 93 in 2003, and n = 51 in 2006).
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ABCC8 p.Ile89Thr 19556559:59:384
status: NEW