ABCC8 p.Lys1384Arg
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PMID: 9755153
[PubMed]
Schwanstecher M et al: "Potassium channel openers require ATP to bind to and act through sulfonylurea receptors."
No.
Sentence
Comment
114
However, by analogy with the results seen with SUR2B, substitution of a lysine for an arginine in either NBF of SUR1 (K719R and/or K1384R) eliminates diazoxide binding and induces a complete loss of activation of SUR1/KIR6.2 channels (results not shown).
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ABCC8 p.Lys1384Arg 9755153:114:131
status: NEW
PMID: 18281290
[PubMed]
Babenko AP et al: "A novel ABCC8 (SUR1)-dependent mechanism of metabolism-excitation uncoupling."
No.
Sentence
Comment
80
Second, K719R plus K1384R in the Walker A motifs eliminated the differences between the two channel activities on-cell and in 1 mM MgATP; the fractions of the Pomax were 0.003 Ϯ 0.0012 and 0.0034 Ϯ 0.0018 versus 0.0025 Ϯ 0.001 and 0.0028 Ϯ 0.0011 for NDSUR1K719RϩK1384R versus SUR1K719RϩK1384R channel, respectively (n ϭ 3 for each).
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ABCC8 p.Lys1384Arg 18281290:80:19
status: NEW