ABCC8 p.Ile1254Val
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PMID: 11118199
[PubMed]
Moreau C et al: "The molecular basis of the specificity of action of K(ATP) channel openers."
No.
Sentence
Comment
60
Within helix H17, L1249 and T1253 were most closely linked to opener activation since mutant SUR2A(L1249T,T1253M) became almost immune to activation, but mutant SUR2A(I1254V,T1255S) kept a wild-type phenotype.
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ABCC8 p.Ile1254Val 11118199:60:167
status: NEW59 Within helix H17, L1249 and T1253 were most closely linked to opener activation since mutant SUR2A(L1249T,T1253M) became almost immune to activation, but mutant SUR2A(I1254V,T1255S) kept a wild-type phenotype.
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ABCC8 p.Ile1254Val 11118199:59:167
status: NEW