PMID: 11118199

Moreau C, Jacquet H, Prost AL, D'hahan N, Vivaudou M
The molecular basis of the specificity of action of K(ATP) channel openers.
EMBO J. 2000 Dec 15;19(24):6644-51., [PubMed]
Sentences
No. Mutations Sentence Comment
59 ABCC8 p.Ile1254Val
X
ABCC8 p.Ile1254Val 11118199:59:167
status: NEW
view ABCC8 p.Ile1254Val details
 Within helix H17, L1249 and T1253 were most closely linked to opener activation since mutant SUR2A(L1249T,T1253M) became almost immune to activation, but mutant SUR2A(I1254V,T1255S) kept a wild-type phenotype. Login to comment 60 ABCC8 p.Ile1254Val
X
ABCC8 p.Ile1254Val 11118199:60:167
status: NEW
view ABCC8 p.Ile1254Val details
 Within helix H17, L1249 and T1253 were most closely linked to opener activation since mutant SUR2A(L1249T,T1253M) became almost immune to activation, but mutant SUR2A(I1254V,T1255S) kept a wild-type phenotype. Login to comment