ABCB1 p.Gly1075Ser
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PMID: 7665554
[PubMed]
Loo TW et al: "Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities."
No.
Sentence
Comment
95
To determine the contribution of either nucleotide-binding domain to drug-stimulatable ATPase activity, mutations were made to the core amino acids (G432S, K433M, G1075S, and K1076M, respectively) of the homology A consensus sequences.
X
ABCB1 p.Gly1075Ser 7665554:95:163
status: NEW123 Mutants K433M, G1075S, and K1076M had no detectable ATPase activities and are omitted for clarity.
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ABCB1 p.Gly1075Ser 7665554:123:15
status: NEW
No.
Sentence
Comment
103
Loo and Clarke [37] extended this approach, showing that the mutations K433M, K1076M, G432S and G1075S in the Homology A sequences of either NBS1 or NBS2 in human Pgp abolish drug-exclusion capability in cells and eliminate ATPase activity in membranes.
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ABCB1 p.Gly1075Ser 8549739:103:96
status: NEW