ABCB1 p.Asp457Arg
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PMID: 21393173
[PubMed]
Leitner I et al: "The third-generation P-glycoprotein inhibitor tariquidar may overcome bacterial multidrug resistance by increasing intracellular drug concentration."
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20
S. aureus 1199B (SA1199B), which overexpresses the major S. aureus multidrug transporter NorA, was generously provided by the Centre for Pharmacognosy and Phytotherapy, University of London.3 S. maltophilia ATCC BAA-85 (also described as D457R) expresses an efflux-mediated MDR system (SmeDEF) against a range of antibacterials, including quinolones.19,20 Antibiotics, chemicals and growth media Mueller-Hinton broth (MHB; Merck, Germany) was adjusted with cations to concentrations of 25 mg/L calcium and 12.5 mg/L magnesium, according to the CLSI.
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ABCB1 p.Asp457Arg 21393173:20:238
status: NEW