PMID: 21393173

Leitner I, Nemeth J, Feurstein T, Abrahim A, Matzneller P, Lagler H, Erker T, Langer O, Zeitlinger M
The third-generation P-glycoprotein inhibitor tariquidar may overcome bacterial multidrug resistance by increasing intracellular drug concentration.
J Antimicrob Chemother. 2011 Apr;66(4):834-9. Epub 2011 Jan 19., [PubMed]
Sentences
No. Mutations Sentence Comment
20 ABCB1 p.Asp457Arg
X
ABCB1 p.Asp457Arg 21393173:20:238
status: NEW
view ABCB1 p.Asp457Arg details
 S. aureus 1199B (SA1199B), which overexpresses the major S. aureus multidrug transporter NorA, was generously provided by the Centre for Pharmacognosy and Phytotherapy, University of London.3 S. maltophilia ATCC BAA-85 (also described as D457R) expresses an efflux-mediated MDR system (SmeDEF) against a range of antibacterials, including quinolones.19,20 Antibiotics, chemicals and growth media Mueller-Hinton broth (MHB; Merck, Germany) was adjusted with cations to concentrations of 25 mg/L calcium and 12.5 mg/L magnesium, according to the CLSI. Login to comment