ABCMdb

ABCB1 p.Trp212*

None has been submitted yet.

Publications

PMID: 21311410 [PubMed] Yamakawa Y et al: "Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia."

No. Sentence Comment

77 Individual Clearance of Imatinib as a Function of Variant Genotypes Allele Region Effect* Number of Patients Allele Frequency† WT Het Var p q SLC22A11022C.T Exon6 P341L 24 8 2 0.82 0.18 SLCO1B1521T.C Exon6 V174A 26 7 1 0.87 0.13 SLCO1B3334T.G Exon3 S112A 5 10 19 0.29 0.71 ABCB11236C.T Exon12 G412G 5 19 10 0.43 0.57 ABCB12677G.T/A Exon21 A893S/T 10 14 10 0.50 0.50 ABCB13435C.T Exon26 I1145I 7 21 6 0.51 0.49 ABCG2421C.A Exon5 Q141K 21 13 0 0.81 0.19 CYP2C9430C.T Exon3 R144C 34 0 0 1.00 0.00 CYP2C91075A.C Exon7 I359L 33 1 0 0.99 0.01 CYP2C19636G.A Exon5 W212X 27 7 0 0.90 0.10 CYP2C19681G.A Exon4 Splice defect 16 13 5 0.66 0.34 CYP2D6100C.T Exon1 P34S 13 16 5 0.62 0.38 CYP2D61846G.A Exon4 Splice defect 34 0 0 1.00 0.00 CYP3A56986A.G Intron3 Splice defect 2 12 20 0.24 0.76 Allele Clearance 6 SD (L/hr) P WT Het Var WT vs Het vs Var WT + Het vs Var WT vs Het + Var SLC22A11022C.T 8.8 6 2.9 8.2 6 3.5 8.3 6 3.5 0.973 0.913 0.926 SLCO1B1521T.C 8.7 6 3.1 8.3 6 2.0 5.5 0.304 0.235 0.288 SLCO1B3334T.G 5.7 6 2.3 7.4 6 2.4 9.5 6 3.1 0.046 0.019 0.071 ABCB11236C.T 11.7 6 3.1 8.1 6 2.7 8.2 6 3.2 0.277 0.642 0.196 ABCB12677G.T/A 9.8 6 3.2 8.1 6 2.5 8.0 6 3.3 0.494 0.445 0.270 ABCB13435C.T 12.7 6 3.0 7.9 6 2.4 9.2 6 3.5 0.058 0.581 0.035 ABCG2421C.A 7.9 6 3.1 9.5 6 2.8 N/A 0.446 N/A 0.462 CYP2C9430C.T 8.3 6 3.0 N/A N/A N/A N/A N/A CYP2C91075A.C 8.6 6 3.0 10.0 N/A 0.508 N/A 0.647 CYP2C19636G.A 8.1 6 2.8 9.7 6 3.3 N/A 0.242 N/A 0.257 CYP2C19681G.A 8.6 6 3.6 9.5 6 2.6 7.0 6 1.1 0.473 0.252 0.852 CYP2D6100C.T 7.3 6 3.2 8.2 6 2.4 12.7 6 3.3 0.190 0.089 0.276 CYP2D61846G.A 8.3 6 3.0 N/A N/A N/A N/A N/A CYP3A56986A.G 6.3 6 1.0 7.9 6 3.4 9.4 6 2.8 0.285 0.323 0.175 *Number represents amino acid codon. Login to comment