ABCB1 p.Ile235Leu
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PMID: 20650928
[PubMed]
Kammerer CM et al: "Localization of genes for V+LDL plasma cholesterol levels on two diets in the opossum Monodelphis domestica."
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109
For ABCB4, the Ile235Leu SNP was genotyped using restriction site-generating PCR (RG-PCR) (27).
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ABCB1 p.Ile235Leu 20650928:109:15
status: NEW175 Association and linkage analyses of variants for INSIG1 and ABCB4 regions All animals with DNA were genotyped for the INSIG1 marker (8M706) and the ABCB4 Ile235Leu SNP.
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ABCB1 p.Ile235Leu 20650928:175:154
status: NEW216 Genotypes of five highand five low-V+LDL responders for three nonsynonymous SNPs and a microsatellite for INSIG1 and ABCB4 INSIG1 ABCB4 Animal ID High or Low V+LDL Group Arg24Gly C/G 8M706 170/172 Ile235Leu A/T Arg29Gly A/G E4855 High CC 172/172 TT GG E0946 High CC 172/172 TT GG E3023 High GG 170/170 AT AG E3030 High CG 170/172 AT AG E3203 High GG 170/170 AT AG E3026 Low CG 170/172 AT AG E3020 Low CG 170/172 AT AG E3198 Low CC 172/172 TT GG E3205 Low GG 170/170 AA AA E3202 Low CG 170/172 AT AG SNP, single-nucleotide polymorphism.
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ABCB1 p.Ile235Leu 20650928:216:197
status: NEW229 However, variation marked by the ABCB4 Ile235Leu SNP genotype is associated with only ~35% of the additive genetic variation in V+LDL cholesterol (Fig. 3), whereas the Mdo 8 QTL accounted for ~65% of the additive genetic variance.
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ABCB1 p.Ile235Leu 20650928:229:39
status: NEW