ABCMdb

PMID: 20650928

Kammerer CM, Rainwater DL, Gouin N, Jasti M, Douglas KC, Dressen AS, Ganta P, Vandeberg JL, Samollow PB
Localization of genes for V+LDL plasma cholesterol levels on two diets in the opossum Monodelphis domestica.
J Lipid Res. 2010 Oct;51(10):2929-39. Epub 2010 Jul 22., [PubMed]

Sentences

No. Mutations Sentence Comment

109 ABCB1 p.Ile235Leu For ABCB4, the Ile235Leu SNP was genotyped using restriction site-generating PCR (RG-PCR) (27). Login to comment 175 ABCB1 p.Ile235Leu Association and linkage analyses of variants for INSIG1 and ABCB4 regions All animals with DNA were genotyped for the INSIG1 marker (8M706) and the ABCB4 Ile235Leu SNP. Login to comment 216 ABCB1 p.Ile235Leu ABCB1 p.Ile235Leu Genotypes of five highand five low-V+LDL responders for three nonsynonymous SNPs and a microsatellite for INSIG1 and ABCB4 INSIG1 ABCB4 Animal ID High or Low V+LDL Group Arg24Gly C/G 8M706 170/172 Ile235Leu A/T Arg29Gly A/G E4855 High CC 172/172 TT GG E0946 High CC 172/172 TT GG E3023 High GG 170/170 AT AG E3030 High CG 170/172 AT AG E3203 High GG 170/170 AT AG E3026 Low CG 170/172 AT AG E3020 Low CG 170/172 AT AG E3198 Low CC 172/172 TT GG E3205 Low GG 170/170 AA AA E3202 Low CG 170/172 AT AG SNP, single-nucleotide polymorphism. Login to comment 229 ABCB1 p.Ile235Leu However, variation marked by the ABCB4 Ile235Leu SNP genotype is associated with only ~35% of the additive genetic variation in V+LDL cholesterol (Fig. 3), whereas the Mdo 8 QTL accounted for ~65% of the additive genetic variance. Login to comment