ABCB1 p.Gly54Arg
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PMID: 18596043
[PubMed]
Loo TW et al: "Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11."
No.
Sentence
Comment
151
By contrast, 12 of the mutants (V53R, G54R, T55R, L56R, A57R, A58R, I59R, I60R, G62R, A63R, P66R, and F72R) showed little or no rescue in the presence of drug substrates.
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ABCB1 p.Gly54Arg 18596043:151:38
status: NEW
PMID: 15563516
[PubMed]
Chen J et al: "Mutations in the cyp51A gene and susceptibility to itraconazole in Aspergillus fumigatus serially isolated from a patient with lung aspergilloma."
No.
Sentence
Comment
133
(b) Another point transition mutation of G160A, which converts glycine into arginine at residue 54 (G54R) in cytochrome P450 sterol 14-a-demethylase, was found in AF4, 5 and 6.
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ABCB1 p.Gly54Arg 15563516:133:100
status: NEW137 The mutation M220I was found in resistant isolate AF2, and the mutation G54R was found in resistant isolates AF4, AF5 and AF6.
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ABCB1 p.Gly54Arg 15563516:137:72
status: NEW148 The G54R mutation is located in a very conserved region, possibly involved in inhibitor- or substrate-induced structure changes in the enzyme molecule.
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ABCB1 p.Gly54Arg 15563516:148:4
status: NEW