ABCMdb

PMID: 15563516

Chen J, Li H, Li R, Bu D, Wan Z
Mutations in the cyp51A gene and susceptibility to itraconazole in Aspergillus fumigatus serially isolated from a patient with lung aspergilloma.
J Antimicrob Chemother. 2005 Jan;55(1):31-7. Epub 2004 Nov 24., [PubMed]

Sentences

No. Mutations Sentence Comment

133 ABCB1 p.Gly54Arg (b) Another point transition mutation of G160A, which converts glycine into arginine at residue 54 (G54R) in cytochrome P450 sterol 14-a-demethylase, was found in AF4, 5 and 6. Login to comment 137 ABCB1 p.Gly54Arg The mutation M220I was found in resistant isolate AF2, and the mutation G54R was found in resistant isolates AF4, AF5 and AF6. Login to comment 148 ABCB1 p.Gly54Arg The G54R mutation is located in a very conserved region, possibly involved in inhibitor- or substrate-induced structure changes in the enzyme molecule. Login to comment