ABCB1 p.Ala841Leu
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PMID: 16442101
[PubMed]
Frelet A et al: "Insight in eukaryotic ABC transporter function by mutation analysis."
No.
Sentence
Comment
519
Loo et al. [256] demonstrated that mutations affecting the processing and targeting of Pgp disrupted interactions between the NBDs such as in DY490, G269V (ICL2), P709G (linker), G722A (TM7) and A841L (TM9).
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ABCB1 p.Ala841Leu 16442101:519:195
status: NEW
PMID: 16691490
[PubMed]
Loo TW et al: "Rescue of folding defects in ABC transporters using pharmacological chaperones."
No.
Sentence
Comment
76
The presence of a processing mutation in either half-molecule (N-half (G268V) or COOH-half (A841L)) resulted in the loss of interactions between the half-molecules.
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ABCB1 p.Ala841Leu 16691490:76:92
status: NEW
PMID: 8995353
[PubMed]
Loo TW et al: "Correction of defective protein kinesis of human P-glycoprotein mutants by substrates and modulators."
No.
Sentence
Comment
64
In addition to the mutants G268V and ⌬Y490, we were able to facilitate processing of P-glycoproteins with mutations in the predicted transmembrane segments (TM1, G54V; TM5, G300V; TM7, A718L; and TM9, A841L), in the extracellular loops between transmembrane segments (G854V), in the cytoplasmic loops (G251V and W803A), in the nucleotide-binding domains (G427C and S434C), and in the linker region connecting the two halves of the molecule (E707A) (data not shown).
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ABCB1 p.Ala841Leu 8995353:64:208
status: NEW
PMID: 9614062
[PubMed]
Loo TW et al: "Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions."
No.
Sentence
Comment
97
We then tested the effect of a misprocessing mutation located in the C-half of P-glycoprotein (A841L), on the ability of the two halves to associate.
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ABCB1 p.Ala841Leu 9614062:97:95
status: NEW99 Wild-type N-Half-A52 was coexpressed in HEK 293 cells with either wild-type C-Half-His or mutant (A841L) C-Half-His, in the presence or absence of CsA.
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ABCB1 p.Ala841Leu 9614062:99:98
status: NEW100 Fig. 3A shows that CsA had a dramatic effect on the association of A841L C-Half-His and wild-type N-Half-A52.
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ABCB1 p.Ala841Leu 9614062:100:67
status: NEW117 A, wild-type N-Half-A52 was coexpressed with wild-type C-Half-His or with mutant (A841L) C-Half-His in the presence (ϩ) or absence (-) of 10 M CsA.
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ABCB1 p.Ala841Leu 9614062:117:82
status: NEW