ABCB1 p.Glu556Cys
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PMID: 15326176
[PubMed]
Tombline G et al: "Properties of P-glycoprotein with mutations in the "catalytic carboxylate" glutamate residues."
No.
Sentence
Comment
174
These Ser residues are known from x-ray crystal- 2 This conclusion was affirmed by unpublished work (I. L. Urbatsch and A. E. Senior) in which we mutated Glu-556 and Glu-1201 to Cys in otherwise Cys-less human MDR1 Pgp (residues 556 and 1201 in human MDR1 are equivalent to 552 and 1197 in mouse MDR3).
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ABCB1 p.Glu556Cys 15326176:174:154
status: NEW