PMID: 15326176

Tombline G, Bartholomew LA, Tyndall GA, Gimi K, Urbatsch IL, Senior AE
Properties of P-glycoprotein with mutations in the "catalytic carboxylate" glutamate residues.
J Biol Chem. 2004 Nov 5;279(45):46518-26. Epub 2004 Aug 23., 2004-11-05 [PubMed]
Sentences
No. Mutations Sentence Comment
174 ABCB1 p.Glu1201Cys
X
ABCB1 p.Glu1201Cys 15326176:174:166
status: NEW
view ABCB1 p.Glu1201Cys details
ABCB1 p.Glu556Cys
X
ABCB1 p.Glu556Cys 15326176:174:154
status: NEW
view ABCB1 p.Glu556Cys details
 These Ser residues are known from x-ray crystal- 2 This conclusion was affirmed by unpublished work (I. L. Urbatsch and A. E. Senior) in which we mutated Glu-556 and Glu-1201 to Cys in otherwise Cys-less human MDR1 Pgp (residues 556 and 1201 in human MDR1 are equivalent to 552 and 1197 in mouse MDR3). Login to comment