ABCMdb

ABCB1 p.Thr769Cys

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Publications

PMID: 14670948 [PubMed] Loo TW et al: "Disulfide cross-linking analysis shows that transmembrane segments 5 and 8 of human P-glycoprotein are close together on the cytoplasmic side of the membrane."

No. Sentence Comment

124 The verapamiland demecolcine-stimulated ATPase activities rel- TABLE I Cross-linking between residues in TMs 5 and 8 TM5 TM 8 F767C I768C T769C F770C F771C L772C Q773C G774C F775C T776C I293C -a - - - - - - - ϩϩb - T294C - - - - - - - - - - A295C - - - - - - - ϩ - - N296C - - - ϩϩb ϩ - ϩ ϩϩc ϩ - I297C - - - ϩd ϩϩ - - ϩϩb - - S298C - - - - - - - - - - I299C - - - ϩϩc - - - ϩϩc - - G300C ϩϩe - - ϩϩc ϩϩb - - ϩϩb ϩ - A301C - - - - - - - - - - A302C - - - - - - - - - - a No cross-linked product detected in SDS-PAGE gels at 37 °C. b Cross-linked product was also detected at 22 °C. c Cross-linked product was also detected at 22 °C and at 4 °C. d Relatively weak cross-linking (Ͻ50% of P-gp cross-linked) at 37 °C. e Relatively strong cross-linking (Ͼ50% of P-gp cross-linked) at 37 °C. FIG. 2. Login to comment

PMID: 25748216 [PubMed] Liu JY et al: "Mechanisms of azole resistance in Candida albicans clinical isolates from Shanghai, China."

No. Sentence Comment

103 of strainsa Site of isolation FLC ITRA VRC Amino acid substitution(s) in Tac1b Missense mutation in TAC1 gene Amino acid substitution(s) in Erg11b Missense mutation in ERG11 gene Gene overexpression Y141 Vagina 16(SDD) >16(R) 0.5(S) S199N, A736V, L935S G596A, C2207T, T2804C A114S, Y205E, Y257H, V437I G340T, T613G or C615A, T769C, G1309A CDR2 Y201 Vagina 16(SDD) 16(R) 1(S) F104V, A736V, L935S T310G, C2207T, T2804C A114S, Y205E, Y257H, V437I G340T, T613G or C615A, T769C, G1309A CDR1 Y205 Vagina 16(SDD) 0.5(SDD) 2(I) D776N, L935S G2326A, T2804C Y132H, Y205E,V437I, G448E T394C, T613G or C615A, G1309A, G1343A CDR1,CDR2 Y206 Vagina 16(SDD) 16(R) 2(I) S199N, D776N, L935S G596A, G2326A, T2804C Y132H, Y205E, V437I, G472R T394C, T613G or C615A, G1309A, G1414A CDR2 Y208 Vagina 32(SDD) 16(R) 1(S) e e Y132H, Y205E, N435V, G448E,D502E T394C, T613G or C615A, A1303G, G1343A, C1506A e Y210 Vagina 16(SDD) 0.25(SDD) 4(R) S199N, N772K, N896S G596A, T2316A, A2687G Y132H, Y205E, Y257H, E260V, V437I, G448E T394C, T613G or C615A, T769C, A779T, G1309A, G1343A CDR1,CDR2 Y203 Vagina 0.5(S) 0.0313(S) <0.0313(S) S199N, L935S G596A, T2804C Y205E, V437I T613G or C615A, G1309A e J026 Sputum 0.5(S) 0.0313(S) 0.0313(S) e e Y205E, V437I T613G or C615A, G1309A e J509 Vagina 32(SDD) 0.25(SDD) 0.25(S) S199N, D776N, L935S G596A, G2326A, T2804C D116E, K128T, Y205E, V437I T348A, A383C, T613G or C615A, G1309A CDR2 J774 Sputum 0.5(S) 0.0313(S) <0.0313(S) e e Y205E, V437I T613G or C615A, G1309A e J5039 Sputum 2(S) 0.0313(S) <0.0313(S) F104V, L935S T310G, T2804C D116E T348A e J5043 Sputum 2(S) 0.0313(S) <0.0313(S) e e Y205E, V437I T613G or C615A, G1309A e H24308 Skin 32(SDD) 0.5(SDD) 0.25(S) S199N, D776N G596A, G2326A, D116E, K128T, K143R, Y205E, V437I T348A, A383C, A428G, T613G or C615A, G1309A CDR2 H75045 Vagina 16(SDD) 0.25(SDD) 2(I) S199N, L935S, F964Y G596A, T2804C, A2890G or A2891T Y132H, Y205E, V437I, G448E T394C, T613G or C 615A, G1309A, G1343A CDR1,CDR2,ERG11 H13139 Skin >64(R) >16(R) 8(R) e e D116E, Y132F, K143Q, Y205E, Y257H T348A, A395T, A427C, T613G or C615A, T769C e H21897 Skin >64(R) >16(R) 16(R) S199N, N772K, N896S G596A, T2316A, A2687G D116E, Y132F, K143Q, Y205E, V437I T348A, A395T, A427C, T613G or C615A, G1309A CDR1,CDR2 H64110 Skin >64(R) 16(R) 4(R) e e D116E, Y132F, K143Q, Y205E, Y257H T348A, A395T, A427C, T613G or C615A, T769C e H30071 Sputum 4(S) <0.0313(S) 0.0313(S) e e D116E T348A e Rc701 Sputum 0.25(S) 0.0313(S) <0.0313(S) e e Y205E, V437I T613G or C615A, G1309A e RC837 Sputum 0.25(S) 0.0313(S) <0.0313(S) S199N, L935S G596A, T2804C D116E T348A e Rc924 Sputum 0.125(S) <0.0313(S) <0.0313(S) F104V, L935S T310G, T2804C Y205E,E226D,V437I T613G or C615A, A789C, G1309A e Rc289 Throat 0.25(S) 0.0313(S) 0.0313(S) e e Y205E, V437I T613G or C615A, G1309A e Rc273 Sputum 0.25(S) <0.0313(S) 0.0313(S) e e D116E, V437I T348A, G1309A e Rc923 Sputum 0.25(S) 0.0313(S) 0.0313(S) S199N, L935S G596A, T2804C Y205E, A255V, V437I T613G or C615A, C764T, G1309A e Rc592 Sputum 0.25(S) 0.0313(S) <0.0313(S) e e D116E, Y205E T348A, T613G or C615A e Rc271 Stool 0.25(S) <0.0313(S) <0.0313(S) F104V, L935S T310G, T2804C D116E, V437I T348A, G1309A e Rc286 Sputum 0.25(S) 0.0313(S) 0.0313(S) e Y205E, V437I T613G or C615A, G1309A e Rc944 Sputum 1(S) 0.0313(S) 0.0313(S) e D116E T348A e Rc963 Throat 0.25(S) 0.0313(S) 0.0313(S) e Y205E, V437I T613G or C615A, G1309A e Rc827 Sputum 0.125(S) <0.0313(S) <0.0313(S) e Y205E, V437I T613G or C615A, G1309A e a Y, Shanghai First Maternity and Infant Hospital at Tonji University School of Medicine. Login to comment