ABCB1 p.Thr199Ala
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PMID: 12019078
[PubMed]
Perea S et al: "Molecular mechanisms of fluconazole resistance in Candida dubliniensis isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis."
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Sentence
Comment
161
mutations (S113F, F148L, T199A, R210G, D288G, G289D, L300P, R398G, and P515S) have not been described in C. albicans.
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ABCB1 p.Thr199Ala 12019078:161:25
status: NEW199 Nucleotide and amino acid substitutions in ERG11 genes from C. dubliniensis clinical isolates Patient no. Isolate FLC MIC (g/ml) Substitutiona S113F V125A F126L F148L T199A R210G D288G G289D L300P G307A R398G V437A G464S P515S 1 3300 1 T374C C378A T1310C 3946 64 C378A A595G A628G 4380 64 G1390A 4713 64 G1390A 4806 64 T442C G920C C1543T 4807 32 A863G T899C T1310C 5143 32 T374C C378A A1192G T1310C 2 3466 0.25 4572 64 C338T G866A a The base numbers are with respect to the first ATG codon of ERG11.
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ABCB1 p.Thr199Ala 12019078:199:175
status: NEW