ABCB1 p.Val437Ala
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PMID: 12019078
[PubMed]
Perea S et al: "Molecular mechanisms of fluconazole resistance in Candida dubliniensis isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis."
No.
Sentence
Comment
143
Four of these mutations (F126L, G307A, V437A, and G464S) have previously been described in azole-resistant C. albicans clinical isolates (16, 18, 19, 28, 36).
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ABCB1 p.Val437Ala 12019078:143:39
status: NEW150 V125L, F126L, and V437A mutations were found in ERG11 genes from both azole-susceptible and azole-resistant C. dubliniensis isolates and therefore are not likely to represent mutations linked with an phenotype of resistance to an azole antifungal agent.
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ABCB1 p.Val437Ala 12019078:150:18
status: NEW189 Four of these mutations (F126L, G307, V437A, and G464S) have been also found in clinical isolates of C. albicans with decreased susceptibilities to FLC, and two of them (G464S and G307A) have been shown to affect the affinity of the enzyme for the azoles.
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ABCB1 p.Val437Ala 12019078:189:38
status: NEW199 Nucleotide and amino acid substitutions in ERG11 genes from C. dubliniensis clinical isolates Patient no. Isolate FLC MIC (g/ml) Substitutiona S113F V125A F126L F148L T199A R210G D288G G289D L300P G307A R398G V437A G464S P515S 1 3300 1 T374C C378A T1310C 3946 64 C378A A595G A628G 4380 64 G1390A 4713 64 G1390A 4806 64 T442C G920C C1543T 4807 32 A863G T899C T1310C 5143 32 T374C C378A A1192G T1310C 2 3466 0.25 4572 64 C338T G866A a The base numbers are with respect to the first ATG codon of ERG11.
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ABCB1 p.Val437Ala 12019078:199:217
status: NEW