ABCB1 p.Phe335Ser
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PMID: 10400654
[PubMed]
Vo QD et al: "Identification of P-glycoprotein mutations causing a loss of steroid recognition and transport."
No.
Sentence
Comment
310
A F335A or F335S change caused increased resistance to doxorubicin.
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ABCB1 p.Phe335Ser 10400654:310:11
status: NEW
PMID: 8104183
[PubMed]
Loo TW et al: "Functional consequences of phenylalanine mutations in the predicted transmembrane domain of P-glycoprotein."
No.
Sentence
Comment
120
To test theeffects of other changes to these two residues, site-directed mutagenesis was used to change either Phe-335 or Phe-978 to serine (polar residue), leucine (small non-polar residue),or to tyrosine (aromatic residue withpolar side chain).
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ABCB1 p.Phe335Ser 8104183:120:111
status: NEW135 A vinblastine/colchicine ratio of 4.1 was obtained for the wild-type enzyme, whereas mutants Phe335 to Ala or Ser hadvalues of 0.59and 0.44respectively.
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ABCB1 p.Phe335Ser 8104183:135:93
status: NEW243 It has been found that mutations of Pro-223 toAla, Pro-866 toAla (Loo and Clarke, 1993), Phe-978 toAla or Ser (this study), and Ser-941 to Phe (Groset al., 1991) yield proteins that have reduced ability to conferresistanceto colchicine butretainthecapacity to conferresistancetovinblastine.The oppositeeffect is observed for mutation of Phe-335 to Ala or Ser (this study) or Gly-185 to Val (Choi et al., 1988).
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ABCB1 p.Phe335Ser 8104183:243:337
status: NEW