ABCMdb

PMID: 10400654

Vo QD, Gruol DJ
Identification of P-glycoprotein mutations causing a loss of steroid recognition and transport.
J Biol Chem. 1999 Jul 16;274(29):20318-27., 1999-07-16 [PubMed]

Sentences

No. Mutations Sentence Comment

37 ABCB1 p.Gly185Val The mutation G185V in the human Pgp causes increased colchicine resistance and decreased vinblastine resistance. Login to comment 209 ABCB1 p.Ala301Thr Thus, the difference was a G to A transition at nucleotide 901 of the coding sequence that resulted in an amino acid change of A301T. Login to comment 220 ABCB1 p.Ala301Val The results show that the W231L change was found in variants from three independent selections, while the A301V change was observed in two independent selections. Login to comment 221 ABCB1 p.Ala301Thr ABCB1 p.Ala301Val The alanine 301 was found to be mutated in two ways, A301T and A301V, by changes at two adjacent bases. Login to comment 301 ABCB1 p.Ala301Thr ABCB1 p.Ala301Val ABCB1 p.Ala301Val ABCB1 p.Ser228Thr Cell linea Drugb Mutation VINC DNR DEX PURO COLC ACT D MSPP-1 (1) NCc 2 222 2 ϩϩϩ NC W231L MSPP-7 (2) NC 22 222 22 ϩϩϩϩ NC W231L MSPP-55 (3) NC 2 222 22 ϩϩϩ NC W231L MSPP-6 (2) ϩ NC 222 22 22 NC H346N MSPP-17 (2) 2 22 222 22 22 NC A301T MSPP-4 (2) NC NC 222 2 2 NC A301V MSPP-35 (3) NC NC 222 NC 2 NC A301V MSPP-21 (2) 2 22 222 2 2 NC S228T a The numbers within the parentheses refer to the selection experiment in which the variant was isolated. Login to comment 310 ABCB1 p.Phe335Ala ABCB1 p.Phe335Ser A F335A or F335S change caused increased resistance to doxorubicin. Login to comment 311 ABCB1 p.Phe335Leu A F335L change caused decreased resistance to doxorubicin. Login to comment