ABCMdb

ABCB1 p.Ala301Val

None has been submitted yet.

Publications

PMID: 10400654 [PubMed] Vo QD et al: "Identification of P-glycoprotein mutations causing a loss of steroid recognition and transport."

No. Sentence Comment

220 The results show that the W231L change was found in variants from three independent selections, while the A301V change was observed in two independent selections. Login to comment
221 The alanine 301 was found to be mutated in two ways, A301T and A301V, by changes at two adjacent bases. Login to comment
301 Cell linea Drugb Mutation VINC DNR DEX PURO COLC ACT D MSPP-1 (1) NCc 2 222 2 ϩϩϩ NC W231L MSPP-7 (2) NC 22 222 22 ϩϩϩϩ NC W231L MSPP-55 (3) NC 2 222 22 ϩϩϩ NC W231L MSPP-6 (2) ϩ NC 222 22 22 NC H346N MSPP-17 (2) 2 22 222 22 22 NC A301T MSPP-4 (2) NC NC 222 2 2 NC A301V MSPP-35 (3) NC NC 222 NC 2 NC A301V MSPP-21 (2) 2 22 222 2 2 NC S228T a The numbers within the parentheses refer to the selection experiment in which the variant was isolated. Login to comment

PMID: 12391288 [PubMed] Gruol DJ et al: "Evidence for the locations of distinct steroid and Vinca alkaloid interaction domains within the murine mdr1b P-glycoprotein."

No. Sentence Comment

117 The A301D mutation occurs in the same residue as the A301T and A301V mutations. Login to comment
204 The mutation expressed in the MSPP-4 cells (A301V) shows the largest reduction of MEK-417 inhibitory activity. Login to comment
206 Thus, it seems unlikely that the (A301V) mutation interferes with the initial binding of Vinca alkaloids with the protein. Login to comment
207 It is possible that A301V promotes the transport of MEK-417 also, which would lead to lower inhibitory activity. Login to comment
298 Multiple mutations were also found at the A301 residue (A301V, A301T, A301D), although much less frequently than the changes at W231. Login to comment