ABCB1 p.Ala301Thr
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PMID: 10400654
[PubMed]
Vo QD et al: "Identification of P-glycoprotein mutations causing a loss of steroid recognition and transport."
No.
Sentence
Comment
209
Thus, the difference was a G to A transition at nucleotide 901 of the coding sequence that resulted in an amino acid change of A301T.
X
ABCB1 p.Ala301Thr 10400654:209:127
status: NEW221 The alanine 301 was found to be mutated in two ways, A301T and A301V, by changes at two adjacent bases.
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ABCB1 p.Ala301Thr 10400654:221:53
status: NEW301 Cell linea Drugb Mutation VINC DNR DEX PURO COLC ACT D MSPP-1 (1) NCc 2 222 2 ϩϩϩ NC W231L MSPP-7 (2) NC 22 222 22 ϩϩϩϩ NC W231L MSPP-55 (3) NC 2 222 22 ϩϩϩ NC W231L MSPP-6 (2) ϩ NC 222 22 22 NC H346N MSPP-17 (2) 2 22 222 22 22 NC A301T MSPP-4 (2) NC NC 222 2 2 NC A301V MSPP-35 (3) NC NC 222 NC 2 NC A301V MSPP-21 (2) 2 22 222 2 2 NC S228T a The numbers within the parentheses refer to the selection experiment in which the variant was isolated.
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ABCB1 p.Ala301Thr 10400654:301:297
status: NEW
PMID: 12391288
[PubMed]
Gruol DJ et al: "Evidence for the locations of distinct steroid and Vinca alkaloid interaction domains within the murine mdr1b P-glycoprotein."
No.
Sentence
Comment
117
The A301D mutation occurs in the same residue as the A301T and A301V mutations.
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ABCB1 p.Ala301Thr 12391288:117:53
status: NEW298 Multiple mutations were also found at the A301 residue (A301V, A301T, A301D), although much less frequently than the changes at W231.
X
ABCB1 p.Ala301Thr 12391288:298:63
status: NEW