ABCC7 p.Arg347Gln
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No.
Sentence
Comment
557
Ineffect of mutations on anion binding suggests that permeant anions can interact with the channel sufficiently confirmation of these results, Smith and Dawson (unpublished data) found that blockade of CFTR by externalstrongly to impede conduction rates but that the ''tight binding`` is dependent on some element of pore conforma- SCN was abolished in R347E and also in R347Q CFTR, confirming the importance of the positive charge at thistion that is not critical to promote the entry of anions into the pore.
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ABCC7 p.Arg347Gln 9922376:557:371
status: NEW