ABCC7 p.His199Cys
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PMID: 9724537
[PubMed]
Akabas MH et al: "Channel-lining residues in the M3 membrane-spanning segment of the cystic fibrosis transmembrane conductance regulator."
No.
Sentence
Comment
113
In contrast, a 1-min application of 10 mM MTSES- significantly inhibited the CFTR-induced currents for the mutants H199C, F200C, W202C, I203C, P205C, Q207C, and L211C (Figure 4).
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ABCC7 p.His199Cys 9724537:113:115
status: NEW167 Thus, in order for the MTS reagents to reach the most cytoplasmic accessible residue in the M3 segment, H199C, the channel must be at least 6 Å in diameter from the extracellular end to the level of His199.
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ABCC7 p.His199Cys 9724537:167:104
status: NEW