ABCC7 p.Ala1136Cys
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PMID: 19381710
[PubMed]
Fatehi M et al: "Novel residues lining the CFTR chloride channel pore identified by functional modification of introduced cysteines."
No.
Sentence
Comment
72
Of 21 cysteine mutants studied, only six significantly altered I-V relationship shape in the absence of external MTS reagents (Fig. 3a), with S1118C, T1121C, T1122C, G1127C and A1136C all causing significant inward rectification and V1129C showing outward rectification.
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ABCC7 p.Ala1136Cys 19381710:72:177
status: NEW76 There was strong overlap between changes in control I-V shape and sensitivity to MTS reagents-only A1136C showed an I-V relationship that was significantly different in shape from wild-type in the absence of MTS reagents (Fig. 3a) but insensitive to charged MTS reagents (Fig. 3b).
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ABCC7 p.Ala1136Cys 19381710:76:99
status: NEW168 Only one mutant that was apparently not affected by MTS reagents (A1136C) had a small effect on the shape of the I-V relationship (Fig. 3a).
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ABCC7 p.Ala1136Cys 19381710:168:66
status: NEW
PMID: 21796338
[PubMed]
Qian F et al: "Functional arrangement of the 12th transmembrane region in the CFTR chloride channel pore based on functional investigation of a cysteine-less CFTR variant."
No.
Sentence
Comment
90
A similar lack of effect following prolonged (>5 min) exposure to such high concentrations of both MTSES and MTSET was also observed in ten out of 19 cysteine-substituted mutants tested (I1131C, I1132C, L1133C, T1134C, L1135C, A1136C, M1137C, I1139C, L1143C, and A1146C).
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ABCC7 p.Ala1136Cys 21796338:90:227
status: NEW