ABCC7 p.Leu1143Cys
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PMID: 15272010
[PubMed]
Chen EY et al: "The DeltaF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator."
No.
Sentence
Comment
158
An example of a mutant that did not show cross-linking, T351C/L1143C, is shown in Fig. 3B.
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ABCC7 p.Leu1143Cys 15272010:158:62
status: NEW
PMID: 21796338
[PubMed]
Qian F et al: "Functional arrangement of the 12th transmembrane region in the CFTR chloride channel pore based on functional investigation of a cysteine-less CFTR variant."
No.
Sentence
Comment
90
A similar lack of effect following prolonged (>5 min) exposure to such high concentrations of both MTSES and MTSET was also observed in ten out of 19 cysteine-substituted mutants tested (I1131C, I1132C, L1133C, T1134C, L1135C, A1136C, M1137C, I1139C, L1143C, and A1146C).
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ABCC7 p.Leu1143Cys 21796338:90:251
status: NEW
PMID: 22352759
[PubMed]
Norimatsu Y et al: "Cystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore."
No.
Sentence
Comment
267
Chen et al.41 did not observe cross-linking of T351C and L1143C with any of the three cross-linking agents.
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ABCC7 p.Leu1143Cys 22352759:267:57
status: NEW