ABCC7 p.Tyr380Cys
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PMID: 11585852
[PubMed]
Smith SS et al: "CFTR: covalent and noncovalent modification suggests a role for fixed charges in anion conduction."
No.
Sentence
Comment
483
The conductance of oocytes expressing the I379C construct was reduced by MTS reagents (MTSET, MTSEA, and MTSES) regardless of charge, whereas the effects of the same reagents on oocytes expressing the Y380C construct were distinctly charge-dependent.
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ABCC7 p.Tyr380Cys 11585852:483:201
status: NEW484 The anionic reagent (MTSES) increased the macroscopic conductance of oocytes expressing Y380C and altered the shape of the I-V plot from outwardly rectifying to nearly linear, whereas cationic reagents (MTSET and MTSEA) reduced the conductance and enhanced the rectification, exactly as predicted for a residue that resides near the mouth of a cation-selective pore.
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ABCC7 p.Tyr380Cys 11585852:484:88
status: NEW485 Single-channel records disclosed that MTS reagents altered the unitary conductance of Y380C channels as would be predicted from macroscopic records, but did not affect channel gating.
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ABCC7 p.Tyr380Cys 11585852:485:86
status: NEW