ABCC7 p.Lys335Ile
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PMID: 10562541
[PubMed]
Tector M et al: "An unstable transmembrane segment in the cystic fibrosis transmembrane conductance regulator."
No.
Sentence
Comment
80
(C) Translation and translocation into microsomes of constructs containing wild-type or doubly mutated, R334L and K335I, Tm6 were analysed by immunoprecipitation with anti-myc antibody (lanes 1, 2, 5 and 6) or a non-relevant control antibody (NRA) (lanes 3 and 7) from TX-100 extracts of the isolated microsomes.
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ABCC7 p.Lys335Ile 10562541:80:114
status: NEW95 Arginine 334 was changed to leucine and lysine 335 to isoleucine, generating construct Tm5-6(RK-LI)-Inv (Figure 3A).
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ABCC7 p.Lys335Ile 10562541:95:40
status: NEW203 These mutations enabled the production of proteins containing leucine in place of arginine 334 and isoleucine in place of lysine 335 in Tm6 of CFTR.
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ABCC7 p.Lys335Ile 10562541:203:99
status: NEW