ABCC1 p.Tyr1236Trp
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PMID: 20004175
[PubMed]
de Foresta B et al: "Interaction with membrane mimics of transmembrane fragments 16 and 17 from the human multidrug resistance ABC transporter 1 (hMRP1/ABCC1) and two of their tryptophan variants."
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Sentence
Comment
67
Similarly, a Ala1227Lys mutant of the TM17 fragment (mTM17) containing Trp1246 (or W20) [37] and the Tyr1236Trp and Trp1246Tyr variant of mTM17 (W10-mTM17), with its Trp closer to the extracellular side in the whole protein, were also synthesized (Table 1).
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ABCC1 p.Tyr1236Trp 20004175:67:101
status: NEW346 For TM17, the Trp variant results from the two point mutations: Y1236W and W1246Y, so that the overall effect on ΔGu (interfacial partitioning free energy of the peptide) is null.
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ABCC1 p.Tyr1236Trp 20004175:346:64
status: NEW