ABCC1 p.Gly1161Pro
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PMID: 16861249
[PubMed]
Ren XQ et al: "A functional role of intracellular loops of human multidrug resistance protein 1."
No.
Sentence
Comment
44
The strategies employed for site-directed mutagenesis of E507L/G511P and E1157L/G1161P in MRP1 cDNA were previously described (10).
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ABCC1 p.Gly1161Pro 16861249:44:80
status: NEW46 We also used a pair of forward and reverse primers to generate E1157L/ G1161P mutations.
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ABCC1 p.Gly1161Pro 16861249:46:71
status: NEW47 The primers were: Forward: 50 TTGC- TGCCGGTCAGCGTCATTCGA30 , and reverse: 50 GGTC- AAGTTGAAATGGGAATA30 (The underlining indicates mismatched bases encoding the E1157L and G1161P mutations, respectively).
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ABCC1 p.Gly1161Pro 16861249:47:171
status: NEW110 ATP-dependent LTC4 transport by reconstituted E507L G511P/WT MRP1 or WT/E1157L G1161P MRP1 was considerably decreased and GSH-dependent photolabeling of azido AG-A of these MRP1 mutants was abrogated.
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ABCC1 p.Gly1161Pro 16861249:110:79
status: NEW
PMID: 17494643
[PubMed]
Letourneau IJ et al: "Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function."
No.
Sentence
Comment
221
Thus, the Glu1157Leu/ Gly1161Pro mutant displayed both decreased vanadate-induced 8N3ADP trapping as well as decreased 8N3ATP photolabeling at both NBDs (Ren et al., 2006).
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ABCC1 p.Gly1161Pro 17494643:221:22
status: NEW223 Unfortunately, the Glu1157Leu/Gly1161Pro mutant was not tested with other substrates, so it is not known whether the decreased transport activity of this mutant was substrate-selective.
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ABCC1 p.Gly1161Pro 17494643:223:30
status: NEW
PMID: 19015228
[PubMed]
Conseil G et al: "Multiple roles of charged amino acids in cytoplasmic loop 7 for expression and function of the multidrug and organic anion transporter MRP1 (ABCC1)."
No.
Sentence
Comment
265
They found that the double-mutant E1157L/G1161P no longer transported LTC4 and could not be labeled with the photoaffinity ligand azidoAgosterol A.
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ABCC1 p.Gly1161Pro 19015228:265:41
status: NEW267 Thus, for reasons that are presently unclear, the interactions of the double E1157L/G1161P mutant with nucleotide differ substantially from those of the CL7 mutants we have described here and elsewhere (Conseil et al., 2006).
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ABCC1 p.Gly1161Pro 19015228:267:84
status: NEW
PMID: 21143116
[PubMed]
He SM et al: "Structural and functional properties of human multidrug resistance protein 1 (MRP1/ABCC1)."
No.
Sentence
Comment
807
The double-mutant Glu1157Leu/Gly1161Pro showed no activity for LTC4 and was not labeled by the photoaffinity ligand azidoAgosterol A [365].
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ABCC1 p.Gly1161Pro 21143116:807:31
status: NEW