ABCC1 p.Asp792Glu
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PMID: 12458196
[PubMed]
Hou YX et al: "ATP binding, not hydrolysis, at the first nucleotide-binding domain of multidrug resistance-associated protein MRP1 enhances ADP.Vi trapping at the second domain."
No.
Sentence
Comment
227
Interestingly, mutation of D792E, which did not significantly change the negative charge at that position, also greatly diminished the ATP enhancement effect on ADP trapping,2 indicating that the distance between the negative charged residue, Asp-792, and the ␥-phosphate of ATP is also very important.
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ABCC1 p.Asp792Glu 12458196:227:27
status: NEW