ABCMdb

PMID: 12458196

Hou YX, Riordan JR, Chang XB
ATP binding, not hydrolysis, at the first nucleotide-binding domain of multidrug resistance-associated protein MRP1 enhances ADP.Vi trapping at the second domain.
J Biol Chem. 2003 Feb 7;278(6):3599-605. Epub 2002 Nov 27., 2003-02-07 [PubMed]

Sentences

No. Mutations Sentence Comment

226 ABCC1 p.Lys684Leu ABCC1 p.Asp792Ala Indeed, mutations of K684L and D792A greatly diminish the ATP enhancing effect on ADP trapping (34). Login to comment 227 ABCC1 p.Asp792Glu Interestingly, mutation of D792E, which did not significantly change the negative charge at that position, also greatly diminished the ATP enhancement effect on ADP trapping,2 indicating that the distance between the negative charged residue, Asp-792, and the ␥-phosphate of ATP is also very important. Login to comment