ABCMdb

ABCC1 p.Glu1089Asp

None has been submitted yet.

Publications

PMID: 11278596 [PubMed] Zhang DW et al: "Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines."

No. Sentence Comment

7 The mutation E1089D showed the same phenotype as MRP1, while the E1089Q substitution markedly decreased resistance to anthracyclines without affecting LTC4 and E217betaG transport. Login to comment
110 Thus, glutamate 1089 was mutated to aspartate, glutamine, alanine, leucine, and lysine and chemosensitivity assays were carried out. Login to comment
116 Typical survival curves for transfectants expressing wild type MRP1 and the mutant proteins E1089Q, E1089D, and E1089K are shown in Fig. 4. Login to comment
146 In view of the effect of mutations of glutamate 1089 in the human protein on resistance to vincristine and VP-16 in addition to the anthracyclines, we also examined LTC4 and E217betaG transport by wild type and mutant human MRP1, including MRP1, E1089Q, E1089D, and E1089K. Login to comment
231 This was supported by the results obtained by substitution of glutamate 1089 with aspartate, which resulted in no detectable change in resistance profile, and by conversion to lysine, which essentially eliminated resistance to both anthracyclines and vincristine, and substantially decreased resistance to VP-16. Login to comment

PMID: 12706887 [PubMed] Grailles M et al: "The Drosophila melanogaster multidrug-resistance protein 1 (MRP1) homolog has a novel gene structure containing two variable internal exons."

No. Sentence Comment

155 Site directed mutagenesis was used to change Glu 1089 to Gln, Asp, Ala, Leu or Lys. Login to comment
153 Site directed mutagenesis was used to change Glu 1089 to Gln, Asp, Ala, Leu or Lys. Login to comment