Mutations at homologous positions to ABCA4 p.Thr1676
Alignment: ABCA_full, Alignment of full length ABCA proteins, 2016-02-18 11:17:15Mutations exactly at the same position:
SNAP2 PROVEAN Effect_dbs |
||
---|---|---|
ABCA4 |
p.Thr1676Pro
|
N
D
?
|
Mutations +/- 5 a.a. around the position:
ABCA1 |
p.Leu1648Pro
|
D
D
?
|
ABCA12 |
p.Thr1980Lys
|
D
N
?
|
ABCA13 |
p.Arg4454Cys
|
N
!
?
|
ABCA7 |
p.Gly1527Ala
|
N
N
?
|
The alignment around the queried position:
ABCA4 1638
I
L
A
L
P
K
D
R
-
S
P
E
E
G
I
T
V
I
S
Q
P
N
L
K
E
Q
L
S
E
I
T
V
L
T
S
V
D
A
V
V
A
I
C
I
F
M
S
F
P
F
V
L
Y
L
I
E
V
N
K
S
K
H
L
F
I
S
1716
ABCA1 1613
I
L
A
N
L
Q
K
G
E
-
N
P
S
H
Y
G
I
T
A
F
N
H
P
L
N
L
T
K
Q
Q
L
S
E
V
A
M
T
T
S
V
D
V
L
V
S
I
V
I
F
A
M
S
F
V
P
S
F
V
F
L
I
Q
E
V
S
K
A
K
H
L
Q
F
I
S
1691
ABCA2 1750
I
L
R
A
N
L
P
K
S
K
G
N
P
A
A
Y
G
I
T
V
T
N
H
P
M
N
K
T
S
A
S
L
S
L
D
Y
L
L
Q
G
-
T
D
V
V
I
A
I
F
I
I
V
A
M
S
F
V
P
A
S
F
V
V
F
L
V
A
E
K
S
T
K
A
K
H
L
Q
F
V
S
1828
ABCA3 1061
L
F
K
L
L
C
G
P
H
-
-
-
-
-
-
S
I
V
V
S
F
P
Q
P
S
A
L
Q
A
K
D
Q
F
N
E
G
R
K
G
F
D
I
A
L
N
L
L
F
A
M
A
F
L
A
S
F
L
V
S
E
R
A
V
Q
A
K
H
V
Q
F
V
S
1134
ABCA5 992
L
Y
H
L
N
V
T
E
T
-
-
-
-
-
-
-
-
-
-
-
-
I
Q
I
W
S
T
P
F
F
Q
E
I
T
D
I
V
F
K
I
E
L
Y
F
Q
A
A
L
L
G
I
I
V
T
A
M
P
P
Y
F
A
M
E
N
A
E
N
H
K
I
K
A
Y
T
Q
L
K
L
S
G
1059
ABCA6 986
L
Q
M
F
N
H
T
Q
H
-
-
-
-
-
-
-
-
-
-
-
-
I
R
I
E
S
S
P
F
P
L
S
-
-
H
I
G
L
W
T
G
L
P
D
G
S
F
F
L
F
L
V
L
C
S
I
S
P
Y
I
T
M
G
S
I
S
D
Y
K
K
N
A
K
S
Q
L
W
I
S
G
1051
ABCA7 1494
I
L
A
H
L
P
P
G
P
-
A
R
A
H
S
I
T
T
L
N
H
P
L
N
L
T
K
E
Q
L
S
E
A
L
M
A
S
S
V
D
V
L
V
S
I
C
V
V
F
A
M
S
F
V
P
A
S
F
T
L
V
L
I
E
E
V
T
R
A
K
H
L
Q
L
M
G
1572
ABCA8 954
L
G
M
V
K
P
S
V
H
-
-
-
-
-
-
-
-
-
-
-
-
I
R
T
E
R
S
T
F
L
E
N
-
-
G
Q
D
N
P
I
G
F
L
A
Y
I
M
F
W
L
V
L
T
S
S
C
P
P
Y
I
A
M
S
S
I
D
D
Y
K
N
R
A
R
S
Q
L
R
I
S
G
1019
ABCA9 995
L
G
I
F
N
S
S
E
H
-
-
-
-
-
-
-
-
-
-
-
-
I
Q
T
D
R
S
T
F
F
E
E
-
-
H
M
D
Y
E
Y
G
Y
R
S
N
T
F
F
W
I
P
M
A
A
S
F
T
P
Y
I
A
M
S
S
I
G
D
Y
K
K
K
A
H
S
Q
L
R
I
S
G
1060
ABCA10 905
M
G
I
F
N
F
T
E
L
-
-
-
-
-
-
-
-
-
-
-
-
I
Q
M
E
S
T
S
F
S
R
D
-
-
D
I
V
L
D
L
G
F
I
D
G
S
I
F
L
L
L
I
T
N
C
V
S
P
F
I
G
M
S
S
I
S
D
Y
K
K
N
V
Q
S
Q
L
W
I
S
G
970
ABCA12 1948
L
L
R
V
N
M
S
-
K
Y
D
A
A
R
-
H
G
I
I
M
Y
S
H
P
Y
P
-
-
G
V
Q
D
Q
E
Q
A
I
S
S
L
I
D
I
L
V
A
L
S
I
L
M
G
Y
S
V
T
T
A
S
F
V
T
Y
V
V
R
E
H
Q
T
K
A
K
Q
L
Q
H
I
S
2023
ABCA13 4416
I
L
W
Q
H
L
P
P
T
V
D
W
R
Q
-
Y
G
I
T
L
Y
S
H
P
Y
G
-
-
G
A
L
L
N
K
D
K
I
L
E
S
I
Q
C
G
V
A
L
C
I
V
G
F
S
I
L
S
A
S
I
G
S
S
V
V
R
D
R
V
I
G
A
K
R
L
Q
H
I
S
4492