Mutations at homologous positions to ABCB1 p.Gln475
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB1 |
p.Gln475Ala
p.Gln475Ser
p.Gln1118Ala
|
D
D
?
D
D
?
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCB1 |
p.Ser474Cys
|
D
D
?
|
| ABCB11 |
p.Ile498Thr
p.Gly499Glu
|
D
D
?
D
D
?
|
| ABCB2 |
p.Gly645Ala
p.Gly645Arg
|
N
N
?
D
D
?
|
| ABCB3 |
p.Glu552Gln
p.Glu552Ala
|
D
D
?
D
D
?
|
| ABCB4 |
p.Val475Ala
p.Pro479Leu
p.Leu481Arg
p.Glu1125Gln
|
D
D
?
D
D
?
D
D
?
D
D
?
|
The alignment around the queried position:
784ABCB1 444
D
P
T
V
-
-
-
-
-
-
-
V
D
I
R
T
I
N
V
R
L
E
I
G
-
V
V
E
P
V
L
F
A
T
T
I
A
E
N
G
E
N
-
-
T
M
E
-
A
V
K
A
A
Y
F
512
ABCB1 1087
P
L
A
K
V
-
-
-
-
-
-
-
L
L
D
E
I
K
R
L
N
V
R
A
H
L
G
-
I
V
S
E
P
I
L
F
D
S
I
A
E
N
I
A
Y
G
D
N
R
V
V
Q
E
-
V
R
A
A
K
E
A
N
I
H
A
1157
ABCB2 615
Y
Q
P
T
G
G
Q
L
L
-
-
-
-
-
-
-
L
D
G
K
P
L
Q
Y
E
H
R
Y
L
H
R
Q
V
A
-
A
V
Q
E
P
Q
V
F
G
R
S
L
Q
E
N
I
A
Y
G
L
T
-
-
K
P
T
M
E
E
I
T
A
A
A
V
K
S
G
A
H
S
F
684
ABCB3 520
Y
Q
P
T
G
G
Q
V
L
-
-
-
-
-
-
-
L
D
E
K
P
I
S
Q
Y
E
H
Y
L
H
S
Q
V
V
-
S
V
G
Q
P
V
L
F
S
G
S
V
R
N
N
I
Y
G
L
-
-
-
Q
S
E
D
D
K
V
A
A
A
Q
A
A
H
A
D
D
F
588
ABCB4 446
Y
D
P
D
G
T
I
N
-
-
-
-
-
-
-
I
D
G
Q
I
R
N
F
N
V
N
L
R
E
I
I
G
-
V
S
Q
E
V
F
S
T
T
I
A
E
N
C
Y
G
R
N
-
-
V
T
M
D
E
-
I
K
K
A
V
K
E
A
Y
E
F
514
ABCB4 1086
Y
D
P
L
A
G
T
V
F
V
D
F
G
F
Q
L
L
D
G
Q
E
A
K
K
L
N
V
Q
W
L
R
A
L
G
-
I
V
S
Q
P
I
L
F
D
C
S
I
A
E
N
A
Y
G
D
N
S
R
V
V
S
Q
D
E
-
I
V
S
A
A
K
A
A
N
I
H
F
1163
ABCB5 622
Y
D
P
V
Q
G
Q
V
-
-
-
-
-
-
-
L
F
D
G
V
D
A
K
E
L
N
V
Q
W
L
R
S
Q
I
A
-
I
V
P
Q
E
P
V
L
F
N
C
S
I
A
E
N
I
A
Y
G
D
N
S
R
V
V
P
L
D
E
-
I
K
E
A
A
N
A
N
I
H
S
F
692
ABCB6 640
Y
D
I
S
S
G
C
I
R
-
-
-
-
-
-
-
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
-
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
R
-
-
-
V
T
A
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
708
ABCB7 522
Y
P
Q
K
G
S
I
Y
-
-
-
-
-
-
-
L
A
G
Q
N
I
Q
D
V
S
L
E
S
L
R
R
A
V
G
-
V
V
P
Q
D
A
V
L
F
H
N
T
I
Y
Y
N
L
L
Y
G
N
-
-
-
I
S
A
S
P
E
E
V
Y
A
V
A
K
L
A
G
L
H
D
A
590
ABCB8 524
Y
D
P
T
A
G
V
V
M
-
-
-
-
-
-
-
L
D
G
R
D
L
R
T
L
D
P
S
W
L
R
G
Q
V
V
G
F
I
S
Q
E
P
V
L
F
G
T
T
I
M
E
N
I
R
F
G
K
-
-
-
L
E
A
S
D
E
E
V
Y
T
A
A
R
E
A
N
A
H
E
F
593
ABCB9 556
Y
P
L
E
G
G
R
V
L
-
-
-
-
-
-
-
L
D
G
K
P
I
S
A
Y
D
H
K
Y
L
H
R
V
I
S
-
L
V
S
Q
E
P
V
L
F
A
R
S
I
T
D
N
I
S
Y
G
L
-
-
-
P
T
V
P
F
E
M
V
V
E
A
A
Q
K
A
N
A
H
G
F
624
ABCB10 544
Y
D
P
A
S
G
T
I
S
-
-
-
-
-
-
-
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
-
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
P
S
S
V
T
A
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
615
ABCB11 472
D
P
C
E
G
M
V
T
-
-
-
-
-
-
-
G
H
D
I
S
L
I
Q
L
R
D
Q
-
I
V
E
Q
E
P
V
L
F
S
T
T
A
E
I
Y
G
E
D
-
-
A
T
M
E
D
-
V
Q
A
A
K
E
A
N
A
Y
N
540
ABCB11 1130
Y
P
D
Q
G
K
V
-
-
-
-
-
-
-
M
I
D
G
H
D
K
N
V
Q
F
L
N
I
G
-
I
V
S
Q
E
P
V
L
F
A
C
S
I
M
D
I
K
Y
G
D
N
T
K
E
P
M
R
-
V
I
A
A
A
K
Q
A
Q
D
F
1200