Mutations at homologous positions to ABCA1 p.Ile883
Alignment: ABCA_full, Alignment of full length ABCA proteins, 2016-02-18 11:17:15Mutations exactly at the same position:
SNAP2 PROVEAN Effect_dbs |
||
---|---|---|
ABCA1 |
p.Ile883Met
|
N
N
?
|
Mutations +/- 5 a.a. around the position:
ABCA1 |
p.Cys887Phe
|
N
N
?
|
ABCA4 |
p.Thr901Ala
p.Thr901Arg
|
D
N
N
N
?
|
The alignment around the queried position:
ABCA1 853
P
R
P
W
Y
F
P
C
T
K
S
Y
W
F
G
-
-
-
-
-
-
-
-
-
E
S
D
E
K
S
H
P
G
S
N
Q
K
R
S
-
-
-
-
-
-
-
-
-
-
-
E
I
M
E
E
E
P
T
H
L
K
L
G
V
S
I
Q
N
L
V
K
V
Y
D
G
M
912
ABCA2 924
P
R
P
W
Y
F
P
L
Q
K
S
Y
W
L
G
S
G
R
T
E
A
W
E
W
S
W
P
W
A
R
T
P
R
L
S
V
M
E
E
D
Q
A
C
A
M
E
S
R
R
F
E
E
T
R
G
M
E
E
E
P
T
H
L
P
L
V
V
C
V
D
K
L
T
K
V
Y
K
D
D
K
1003
ABCA3 481
P
Q
P
W
Y
F
F
I
M
P
S
Y
W
C
G
K
-
-
-
-
-
-
-
-
P
R
A
V
A
G
K
E
E
E
D
S
D
P
E
K
A
L
R
-
-
-
-
-
-
-
-
-
N
E
Y
F
E
A
P
E
D
L
V
A
G
I
K
I
K
H
L
S
K
V
F
R
V
G
N
543
ABCA4 868
L
P
W
Y
L
L
E
S
Y
W
L
G
G
-
E
C
S
T
R
E
E
R
A
L
E
E
P
L
E
E
T
E
D
P
E
H
P
E
G
I
-
-
-
-
D
S
F
F
E
R
E
H
P
G
W
V
P
G
V
C
K
N
L
K
I
E
C
G
942
ABCA5 429
R
S
S
L
Y
F
L
K
P
S
Y
W
S
K
S
-
-
-
-
-
-
-
-
K
R
N
Y
E
E
L
S
E
G
N
V
N
G
N
I
S
F
S
E
-
-
-
-
-
-
-
-
I
I
E
P
V
S
S
E
F
V
G
K
E
A
I
R
I
S
G
I
Q
K
T
Y
R
K
K
G
E
492
ABCA6 429
Y
S
P
L
F
F
L
N
S
S
S
C
F
Q
H
-
-
-
-
-
-
-
-
Q
R
T
N
A
K
V
I
E
K
E
I
D
A
E
H
P
S
D
D
-
-
-
-
-
-
-
-
Y
F
E
P
V
A
P
E
F
Q
G
K
E
A
I
R
I
R
N
V
K
K
E
Y
K
G
K
S
G
492
ABCA7 762
P
E
P
W
F
P
F
R
R
S
Y
W
C
G
-
-
-
-
-
-
-
-
-
P
R
P
-
P
K
S
P
A
P
C
P
T
P
L
D
P
-
-
-
-
-
-
-
-
-
-
-
K
V
L
V
E
E
A
P
P
G
L
S
P
G
V
S
V
R
S
L
E
K
R
F
P
G
S
P
820
ABCA8 431
R
P
P
L
F
F
L
K
S
S
F
W
S
Q
T
-
-
-
-
-
-
-
-
Q
K
T
D
H
V
A
L
E
D
E
M
D
A
D
P
S
F
H
D
-
-
-
-
-
-
-
-
S
F
E
Q
A
P
P
E
F
Q
G
K
E
A
I
R
I
R
N
V
T
K
E
Y
K
G
K
P
D
494
ABCA9 432
C
S
P
L
F
F
L
K
S
C
F
W
F
Q
H
-
-
-
-
-
-
-
-
G
R
A
N
H
V
V
L
E
N
E
T
D
S
D
P
T
P
N
D
-
-
-
-
-
-
-
-
C
F
E
P
V
S
P
E
F
C
G
K
E
A
I
R
I
K
N
L
K
K
E
Y
A
G
K
C
E
495
ABCA10 342
D
S
P
L
F
F
L
K
S
S
F
W
S
K
H
-
-
-
-
-
-
-
-
Q
N
T
H
H
E
I
F
E
N
E
I
N
P
E
H
S
S
D
D
-
-
-
-
-
-
-
-
S
F
E
P
V
S
P
E
F
H
G
K
E
A
I
R
I
R
N
V
I
K
E
Y
N
G
K
T
G
405
ABCA12 1282
A
A
P
W
Y
F
P
I
L
P
S
Y
K
E
R
-
F
G
C
A
E
V
K
P
E
K
S
N
G
L
M
F
T
N
I
M
M
Q
N
T
N
P
S
A
S
P
E
-
Y
M
F
S
S
N
I
E
P
E
P
K
D
L
T
V
G
V
A
L
H
G
V
T
K
I
Y
G
-
-
-
1357
ABCA13 3784
R
K
P
W
Y
F
P
F
T
A
S
Y
W
K
S
V
G
F
L
V
E
K
R
Q
Y
F
L
S
S
S
L
F
F
F
N
E
N
F
D
N
K
G
S
S
L
Q
-
-
-
-
-
-
-
-
N
R
E
G
E
L
E
G
S
A
P
G
V
T
L
V
S
V
T
K
E
Y
E
G
-
-
3854