Mutations at homologous positions to ABCB11 p.Arg487
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB11 |
p.Arg487His
p.Arg487Pro
p.Arg487Leu
p.Lys1145Asn
|
D
D
?
D
D
?
D
D
?
N
D
?
|
| ABCB2 |
p.Pro630Ala
|
N
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCB11 |
p.Asp482Gly
p.Asn490Asp
p.Ser1144Arg
p.Val1147*
|
D
D
?
N
D
?
N
N
?
-
-
?
|
| ABCB1 |
p.Gly455Ala
p.Gln456Cys
p.Asp457Arg
p.Gly1098Ala
p.Lys1099Glu
p.Gln1107Pro
|
D
D
?
N
D
?
D
D
?
D
D
?
N
N
?
D
D
?
|
| ABCB3 |
p.Cys540His
|
N
N
?
|
| ABCB4 |
p.Asp459Gly
p.Asp459His
|
D
D
?
D
D
?
|
The alignment around the queried position:
767ABCB11 455
P
S
G
G
S
A
L
L
I
Q
F
D
P
C
E
G
M
V
T
-
-
-
-
-
-
-
G
H
D
I
S
L
I
Q
L
R
D
Q
-
I
V
E
Q
E
P
V
L
F
S
T
T
A
E
I
Y
G
E
D
-
-
A
T
524
ABCB1 427
T
T
M
Q
R
D
P
T
V
-
-
-
-
-
-
-
V
D
I
R
T
I
N
V
R
L
E
I
G
-
V
V
E
P
V
L
F
A
T
T
I
A
E
N
G
E
N
-
-
T
496
ABCB1 1070
V
V
L
L
E
P
L
A
K
V
-
-
-
-
-
-
-
L
L
D
E
I
K
R
L
N
V
R
A
H
L
G
-
I
V
S
E
P
I
L
F
D
S
I
A
E
N
I
A
Y
G
D
N
R
V
V
1141
ABCB2 598
G
P
N
G
S
G
K
S
T
V
L
L
Q
N
L
Y
Q
P
T
G
G
Q
L
L
-
-
-
-
-
-
-
L
D
G
K
P
L
Q
Y
E
H
R
Y
L
H
R
Q
V
A
-
A
V
Q
E
P
Q
V
F
G
R
S
L
Q
E
N
I
A
Y
G
L
T
-
-
K
P
667
ABCB3 503
G
P
N
G
S
G
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
Q
V
L
-
-
-
-
-
-
-
L
D
E
K
P
I
S
Q
Y
E
H
Y
L
H
S
Q
V
V
-
S
V
G
Q
P
V
L
F
S
G
S
V
R
N
N
I
Y
G
L
-
-
-
Q
S
571
ABCB4 429
G
S
C
G
S
T
T
V
Q
L
I
Q
L
Y
D
P
D
G
T
I
N
-
-
-
-
-
-
-
I
D
G
Q
I
R
N
F
N
V
N
L
R
E
I
I
G
-
V
S
Q
E
V
F
S
T
T
I
A
E
N
C
Y
G
R
N
-
-
V
T
498
ABCB4 1069
G
S
G
G
S
T
V
Q
L
E
R
F
Y
D
P
L
A
G
T
V
F
V
D
F
G
F
Q
L
L
D
G
Q
E
A
K
K
L
N
V
Q
W
L
R
A
L
G
-
I
V
S
Q
P
I
L
F
D
C
S
I
A
E
N
A
Y
G
D
N
S
R
V
V
S
1147
ABCB5 605
G
S
S
G
C
G
K
S
T
S
V
Q
L
L
Q
R
L
Y
D
P
V
Q
G
Q
V
-
-
-
-
-
-
-
L
F
D
G
V
D
A
K
E
L
N
V
Q
W
L
R
S
Q
I
A
-
I
V
P
Q
E
P
V
L
F
N
C
S
I
A
E
N
I
A
Y
G
D
N
S
R
V
V
P
676
ABCB6 623
G
P
S
G
A
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
I
R
-
-
-
-
-
-
-
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
-
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
R
-
-
-
V
T
A
691
ABCB7 505
G
G
S
G
S
G
K
S
T
I
V
R
L
L
F
R
F
Y
P
Q
K
G
S
I
Y
-
-
-
-
-
-
-
L
A
G
Q
N
I
Q
D
V
S
L
E
S
L
R
R
A
V
G
-
V
V
P
Q
D
A
V
L
F
H
N
T
I
Y
Y
N
L
L
Y
G
N
-
-
-
I
S
A
573
ABCB8 507
G
Q
S
G
G
G
K
T
T
V
A
S
L
L
E
R
F
Y
D
P
T
A
G
V
V
M
-
-
-
-
-
-
-
L
D
G
R
D
L
R
T
L
D
P
S
W
L
R
G
Q
V
V
G
F
I
S
Q
E
P
V
L
F
G
T
T
I
M
E
N
I
R
F
G
K
-
-
-
L
E
A
576
ABCB9 539
G
P
S
G
S
G
S
S
C
V
N
I
L
E
N
F
Y
P
L
E
G
G
R
V
L
-
-
-
-
-
-
-
L
D
G
K
P
I
S
A
Y
D
H
K
Y
L
H
R
V
I
S
-
L
V
S
Q
E
P
V
L
F
A
R
S
I
T
D
N
I
S
Y
G
L
-
-
-
P
T
V
607
ABCB10 527
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
-
-
-
-
-
-
-
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
-
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
P
S
S
V
598
ABCB11 1113
G
S
C
G
K
T
S
I
Q
L
L
E
F
Y
P
D
Q
G
K
V
-
-
-
-
-
-
-
M
I
D
G
H
D
K
N
V
Q
F
L
N
I
G
-
I
V
S
Q
E
P
V
L
F
A
C
S
I
M
D
I
K
Y
G
D
N
T
K
E
P
1184