PMID: 9950764

Vanoye CG, Castro AF, Pourcher T, Reuss L, Altenberg GA
Phosphorylation of P-glycoprotein by PKA and PKC modulates swelling-activated Cl- currents.
Am J Physiol. 1999 Feb;276(2 Pt 1):C370-8., [PubMed]
Sentences
No. Mutations Sentence Comment
12 ABCB1 p.Ser671Ala
X
ABCB1 p.Ser671Ala 9950764:12:181
status: NEW
view ABCB1 p.Ser671Ala details
ABCB1 p.Ser671Ala
X
ABCB1 p.Ser671Ala 9950764:12:182
status: NEW
view ABCB1 p.Ser671Ala details
 We measured whole cell swelling-activated Cl-currents (ICl,swell) in parental cells and cells expressing wild-type MDR1 or a phosphorylation-defective mutant (Ser-661, Ser-667, and Ser-671 replaced by Ala). Login to comment 50 ABCB1 p.Ser671Ala
X
ABCB1 p.Ser671Ala 9950764:50:71
status: NEW
view ABCB1 p.Ser671Ala details
 Site-directed mutagenesis was used to substitute Ser-661, Ser-667, and Ser-671 with Ala, and both MDR1 and MDR1-3SA contain six histidine residues at the COOH-terminal end. Login to comment 143 ABCB1 p.Ser671Ala
X
ABCB1 p.Ser671Ala 9950764:143:144
status: NEW
view ABCB1 p.Ser671Ala details
 In summary, PKA and PKC stimulation produced distinct effects on ICl,swell, and these effects were abolished by replacing Ser-661, Ser-667, and Ser-671 with Ala residues. Login to comment