PMID: 9843919

Cressman VL, Hicks EM, Funkhouser WK, Backlund DC, Koller BH
The relationship of chronic mucin secretion to airway disease in normal and CFTR-deficient mice.
Am J Respir Cell Mol Biol. 1998 Dec;19(6):853-66., [PubMed]
Sentences
No. Mutations Sentence Comment
18 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 9843919:18:155
status: NEW
view ABCC7 p.Ser489* details
 We used this technique to create a mouse line (Cftrm1Unc ) in which the Cftr gene was inactivated by introduction of an in-frame stop codon (termed allele S489X) that resulted in the production of a truncated gene product similar to that seen in some human CF patients (4). Login to comment 115 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 9843919:115:129
status: NEW
view ABCC7 p.Ser489* details
 Results Induction of Goblet Cell Hyperplasia in BALB/c, C57BL/6, DBA/2, and 129/SvEv Strains The genetic background on which the S489X mutation is carried consists of a mixture of the BALB/c, C57BL/6, DBA/2, and 129/SvEv mouse strains. Login to comment